Post by Toasty on Oct 9, 2014 20:48:49 GMT
You guys can start testing receptors for yourselves by first becoming familiar with the effects of drugs that only hit one receptor.
When you isolate a receptor, you can watch its effects on the body more closely and learn how to identify it in other substances. The more isolated a receptor is, the less you have to cross reference the effects you observe with other substances known to have similar receptor profiles.
You may be able to make the effects more prominent by taking pure acetylcholinesterase inhibitors, such as the beta-pinene that is in balsam fir, galbanum, and pine oils. This is likely what allowed me to observe everything in detail.
Keep in mind that many receptors have important effects on other receptors. This will play into the effects you feel just by activating the first receptor alone. For example, D1 receptors very strongly upregulate AMPA receptors. You will see both the effects of D1 and AMPA at once. AMPA also upregulates D3 a little bit so you may see that integrated with D1 as well. This can feel confusing, but it's pretty cool to see the downstream cascade that each receptor causes in the brain.
Tea tree oil contains gamma-terpinene, which is a short lasting D1 dopamine receptor agonist. This is pretty much the only receptor tea tree oil affects. You can use this to become familiar with the effects of the D1 dopamine receptor. If you can, try to look in your mind's eye to see a yellow colored energy. I see it repeatably, so there is probably a way for others to discover it as well.
Peppermint oil contains menthol, which is a kappa opioid receptor agonist. This is pretty much all it affects, so through this you can become familiar with the effects of kappa.
Lysine is a 5-HT4 serotonin receptor antagonist. Its effects are noticeable below 300-500 mg, but somewhere above a threshold that I've not yet pinpointed its psychoactivity basically vanishes. So it's still safe to take in large amounts.
I should be able to find a pure 5-HT1a agonist if I look around for a while. I know the effects it causes but I can't remember a pure one off the top of my head. You could take orange oil, whose only two effects are 5-HT1a agonism and 5-HT4 antagonism. (Since the 5-HT4 antagonism comes a little while after the 5-HT1a, I think limonene is a 5-HT1A agonist and its metabolite is a 5-HT4 antagonist... or limonene itself is a 5-HT4 agonist.)
And once you know 5-HT1A and 5-HT4, you could take lime oil to discover 5-HT7. It is almost the same as orange oil, but it also has a short lasting 5-HT7 agonist. I would love to figure out which specific compound in the oil does this, so it too could be isolated and observed more deeply.
Lemon oil is basically lime oil + gamma-terpinene + beta-pinene. Maybe with a higher ratio of 5-HT7.
Garlic is a pure NMDA receptor antagonist. Take it in high doses to scope out this receptor.
When you isolate a receptor, you can watch its effects on the body more closely and learn how to identify it in other substances. The more isolated a receptor is, the less you have to cross reference the effects you observe with other substances known to have similar receptor profiles.
You may be able to make the effects more prominent by taking pure acetylcholinesterase inhibitors, such as the beta-pinene that is in balsam fir, galbanum, and pine oils. This is likely what allowed me to observe everything in detail.
Keep in mind that many receptors have important effects on other receptors. This will play into the effects you feel just by activating the first receptor alone. For example, D1 receptors very strongly upregulate AMPA receptors. You will see both the effects of D1 and AMPA at once. AMPA also upregulates D3 a little bit so you may see that integrated with D1 as well. This can feel confusing, but it's pretty cool to see the downstream cascade that each receptor causes in the brain.
Tea tree oil contains gamma-terpinene, which is a short lasting D1 dopamine receptor agonist. This is pretty much the only receptor tea tree oil affects. You can use this to become familiar with the effects of the D1 dopamine receptor. If you can, try to look in your mind's eye to see a yellow colored energy. I see it repeatably, so there is probably a way for others to discover it as well.
Peppermint oil contains menthol, which is a kappa opioid receptor agonist. This is pretty much all it affects, so through this you can become familiar with the effects of kappa.
Lysine is a 5-HT4 serotonin receptor antagonist. Its effects are noticeable below 300-500 mg, but somewhere above a threshold that I've not yet pinpointed its psychoactivity basically vanishes. So it's still safe to take in large amounts.
I should be able to find a pure 5-HT1a agonist if I look around for a while. I know the effects it causes but I can't remember a pure one off the top of my head. You could take orange oil, whose only two effects are 5-HT1a agonism and 5-HT4 antagonism. (Since the 5-HT4 antagonism comes a little while after the 5-HT1a, I think limonene is a 5-HT1A agonist and its metabolite is a 5-HT4 antagonist... or limonene itself is a 5-HT4 agonist.)
And once you know 5-HT1A and 5-HT4, you could take lime oil to discover 5-HT7. It is almost the same as orange oil, but it also has a short lasting 5-HT7 agonist. I would love to figure out which specific compound in the oil does this, so it too could be isolated and observed more deeply.
Lemon oil is basically lime oil + gamma-terpinene + beta-pinene. Maybe with a higher ratio of 5-HT7.
Garlic is a pure NMDA receptor antagonist. Take it in high doses to scope out this receptor.
